Author

Remko Goossens

Leiden University Medical CenterORCID 0000-0002-8829-4378Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:ChIP-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Approach:statistical model· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alfred C.O. VertegaaliD· 1 shared Annemieke M Aartsma-RusiD· 1 shared Fred Schnell· 1 shared Iris M. WillemseniD· 1 shared Judit BalogiD· 1 shared Kirsten R. Straasheijm· 1 shared Mara S. TihayaiD· 1 shared Nisha E. Verwey· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperMolecular Biology

Alfred C.O. VertegaalORCID

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2 papers

Recent·Most cited

SUMOylation differentially regulates SMCHD1 complex formation and function in a genomic context-specific manner

Remko Goossens, Mara S. Tihaya, Iris M. Willemsen, Kirsten R. Straasheijm, Patrick J. van der Vliet, Román González‐Prieto, Alfred C.O. Vertegaal, Stephen J. Tapscott, Judit Balog, Silvère M. van der Maarel

This study shows SUMOylation of SMCHD1 regulates its function at different genomic loci, affecting chromatin structure and DUX4 expression in FSHD.

bioRxiv · Oct 13, 2024 · PreprintMolecular Biology

DMD antisense oligonucleotide mediated exon skipping efficiency is affected by flanking intron retention time and target position within the exon

Remko Goossens, Nisha E. Verwey, Yavuz Ariyürek, Fred Schnell, Annemieke M Aartsma-Rus

This study evaluates how exon skipping efficiency by antisense oligonucleotides in DMD is influenced by intron retention time and AON position within the exon.

RNA Biology · Sep 4, 2023Peer-reviewedGenetics