NeurosciencebioRxivPreprint
C9orf72-derived poly-GA DPRs undergo endocytic uptake in iNPC-derived astrocytes and spread to motor neurons
Paolo M. Marchi, Lara Marrone, Laurent Brasseur…·Mimoun Azzouz
This study shows poly-GA DPRs are taken up by astrocytes via endocytosis, spread to motor neurons, and cause axonal swellings through lysosomal dysfunction.
DOI 10.1101/2021.10.11.463891