Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells
Tianyi Yang, Jung-Sik Kim, Clara Mellows, Wanying Xu, Alvin Ya, Lisa Sadzewicz, Luke J. Tallon, Jann Nagina Sarkaria, Fulai Jin, Todd A. Waldman
This study shows that restoring STAG2 in STAG2-mutant cancer cells rapidly reduces global chromatin loop size, with limited transcriptional changes, including induction of EFEMP1.
Journal of Biological Chemistry · Jun 23, 2026Peer-reviewedCancer Biology