Cancer BiologyJournal of Biological ChemistryPeer-reviewed
Rapid reduction in global chromatin loop size after acute STAG2 reconstitution in human cancer cells
Tianyi Yang, Jung-Sik Kim, Clara Mellows…·Todd A. Waldman
This study shows that restoring STAG2 in STAG2-mutant cancer cells rapidly reduces global chromatin loop size, with limited transcriptional changes, including induction of EFEMP1.