D-lactate derived from intestinal bacteria drives lysine D-lactylation to modulate transcription in liver cells
Yong Zang, Jianji Zhang, Mingxin Xia, Aiyuan Wang, Zilong Fan, Yanpu Han, Hui Zhang, Siyu Wang, Ziping Niu, Jingya Wu, Xue Bai, Shanshan Tian, Chen Chen, Guijin Zhai, Hanyang Dong, , Kai Zhang
This study shows that D-lactate from intestinal bacteria induces lysine D-lactylation in liver cells, modulating transcription and inhibiting hepatocellular carcinoma cell proliferation.
bioRxiv · Oct 4, 2024 · PreprintMolecular Biology