Hua Li

TRIP6 condensates constrain Hippo pathway hyperactivation under osmotic stress

This study shows TRIP6 condensates regulate Hippo pathway activity under osmotic stress by modulating LATS1 and YAP phosphorylation, preventing excessive pathway activation.

Immortalization and Characterization of Schwann Cell Lines Derived from NF1 Associated Cutaneous Neurofibromas

The paper develops and characterizes semi-immortalized Schwann cell lines from NF1-associated cutaneous neurofibromas to aid in studying and developing therapies for NF1.

Robust Acquisition of High Resolution Spatial Transcriptomes from Preserved Tissues with Immunofluorescence Based Laser Capture Microdissection

This paper introduces a method to obtain high-resolution spatial transcriptomes from preserved tissues using immunofluorescence-based laser capture microdissection, demonstrating its effectiveness in analyzing transcript isoforms in mouse small intestine cells.

The SAGA core module is critical during Drosophila oogenesis and is broadly recruited to promoters

The paper investigates the role of the SAGA core module during Drosophila oogenesis and finds it is genetically essential despite the enzymatic modules being dispensable.

Parallel control of mechanosensory hair cell orientation by the PCP and Wnt pathways

The paper shows that PCP and Wnt pathways independently control hair cell orientation in zebrafish lateral line, with Wnt mutants causing concentric patterns and PCP mutants causing random orientations.

Androgen Promotes Differentiation of PLZF+ Spermatogonia pool via Indirect Regulatory Pattern

This study shows androgen promotes differentiation of PLZF+ spermatogonia via an indirect regulatory pathway involving Sertoli cells and multiple intermediate molecules.

ClusterMap: Comparing analyses across multiple Single Cell RNA-Seq profiles

ClusterMap compares multiple single-cell RNA-Seq profiles by matching sub-types across samples and quantifying similarity and separability.