Author

Alice Gilman‐Sachs

Rosalind Franklin University of Medicine and ScienceORCID 0000-0002-8947-1436Unclaimed ORCID profile · follow to get notified of new preprints

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Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Daniel A. PetersoniD· 1 shared Grace E. StutzmanniD· 1 shared Israel SekleriD· 1 shared Robert A. MarriD· 1 shared Sarah Mustaly-Kalimi· 1 shared Wacey GallegosiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperNeuroscience

Daniel A. PetersonORCID

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1 paper

Recent·Most cited

NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedNov 28, 2022

Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease

Sarah Mustaly-Kalimi, Wacey Gallegos, Robert A. Marr…·Grace E. Stutzmann

This study identifies calcium dysregulation via RyR as a driver of lysosomal dysfunction and protein aggregation in Alzheimer's disease, showing that dantrolene can restore proteolytic activity in AD models.

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