Author

Sarah Mustaly-Kalimi

Rosalind Franklin University of Medicine and Science

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1

Frequent Co-Authors

Daniel A. PetersoniD· 2 shared Grace E. StutzmanniD· 2 shared Israel SekleriD· 2 shared Robert A. MarriD· 2 shared Wacey GallegosiD· 2 shared Alice Gilman‐SachsiD· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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2 shared papersNeuroscience

Daniel A. PetersonORCID

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2 papers

Recent·Most cited

NeurosciencebioRxivPreprintOct 11, 2024

Mitochondrial Dysfunction in Alzheimer's Disease Is Driven By Excess ER-Calcium Release in Patient-Derived Neurons

Sarah Mustaly-Kalimi, Wacey Gallegos, Robert A. Marr…·Grace E. Stutzmann

This study shows that excess ER-Ca2+ release via RyR contributes to mitochondrial dysfunction in AD neurons, leading to cellular pathology and that pharmacological inhibition of RyR-Ca2+ release can reverse these effects.

1 citation

humanbulk RNA-seq

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NeuroscienceProceedings of the National Academy of SciencesPeer-reviewedNov 28, 2022

Protein mishandling and impaired lysosomal proteolysis generated through calcium dysregulation in Alzheimer's disease

Sarah Mustaly-Kalimi, Wacey Gallegos, Robert A. Marr…·Grace E. Stutzmann

This study identifies calcium dysregulation via RyR as a driver of lysosomal dysfunction and protein aggregation in Alzheimer's disease, showing that dantrolene can restore proteolytic activity in AD models.

55 citationstop 2%

humanmouse

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