Heike Siebert

A three-node Turing gene circuit forms periodic spatial patterns in bacteria

The paper engineers a synthetic three-node Turing gene circuit in E. coli that generates periodic spatial patterns, validated by a differential equation model.

The Design Principles of Discrete Turing Patterning Systems

This study compares continuous and discrete models of Turing patterns, finding discrete models more robust and suggesting deeper principles in Turing mechanisms.

A framework for designing miRNA-based distributed cell classifier circuits

This paper presents a framework for designing and evaluating miRNA-based distributed cell classifiers, showing improved prediction accuracy over single-circuit designs.

Identifying lncRNA-mediated regulatory modules via ChIA-PET network analysis

The paper develops a graph analysis method combining co-expression and ChIA-PET data to identify lncRNA-mediated regulatory modules in K562 cells, finding enriched disease associations and functional roles for lncRNAs.

Designing Distributed Cell Classifier Circuits using a Genetic Algorithm

This paper designs distributed cell classifiers using a genetic algorithm to improve accuracy and flexibility in cancer-type specific cell targeting.