Natalie S. Scholes

Monovalent Pseudo-Natural Product Degraders Supercharge the Native Degradation of IDO1 by KLHDC3

The paper identifies iDegs, which enhance IDO1 degradation via the native CRL2KLHDC3 pathway, reducing kynurenine formation and offering new therapeutic potential for cancer.

Inhibitor-induced supercharging of kinase turnover via endogenous proteolytic circuits

The paper identifies inhibitor-induced kinase destabilization as a common phenomenon and reveals that it occurs through endogenous proteolytic mechanisms rather than classical ubiquitination.

A three-node Turing gene circuit forms periodic spatial patterns in bacteria

The paper engineers a synthetic three-node Turing gene circuit in E. coli that generates periodic spatial patterns, validated by a differential equation model.

Turing patterns are common but not robust

The paper explores Turing pattern design space to determine how common and robust they are, finding that they are common but sensitive to parameter changes.