Author

Chuan He

Yale UniversityORCID 0000-0002-8978-2410Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:batch correction / integration· 1 Research Focus:benchmarking· 1 Research Focus:clustering· 1 Approach:deep learning· 1 Research Focus:dimensionality reduction· 1 Assay:scRNA-seq· 1 Approach:variational autoencoder· 1

Frequent Co-Authors

Leying GuaniD· 1 shared Paraskevas FilippidisiD· 1 shared Steven H. KleinsteiniD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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3 top collaborators · 3 mutual co-author links

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1 shared paperBioinformatics

Leying GuanORCID

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1 paper

Recent·Most cited

BioinformaticsCommunications BiologyPeer-reviewedApr 4, 2025

Partially characterized topology guides reliable anchor-free scRNA integration

Chuan He, Paraskevas Filippidis, Steven H. Kleinstein, Leying Guan

The paper introduces scCRAFT, an autoencoder for scRNA-seq batch integration that outperforms existing methods by preserving biological heterogeneity and handling unbalanced batches and rare cell types.

6 citations

scRNA-seqdeep learning

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