Performance of Rilpivirine-Based Hydrophobic Tags and PROTACs Directed Against HIV-1 Reverse Transcriptase
Ferdinand K. Amanor, Garrett D. Clements, Rabia Khurshid, Anna F Howard, Diana M. Soto-Martínez, Courtney A. Barkley, Zhengrong W. Yang, Kabita Gyawali, John C. Kappes, Robert C. Reynolds, Stephan C. Schürer, Timothy S. Snowden, Christina Ochsenbauer
The paper evaluates rilpivirine-based hydrophobic tags and PROTACs for HIV-1 RT degradation, finding that PEG4-Ad shows low nanomolar potency but limited efficacy against resistance mutations.
bioRxiv · Sep 25, 2026 · PreprintMicrobiology