Author

Selket Delafontaine

Universitair Ziekenhuis LeuvenORCID 0000-0002-8985-8155Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetic & Genomic Medicine· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Isabelle MeytsiD· 2 shared Alberto IannuzzoiD· 1 shared Alexander HoischeniD· 1 shared Alexandra K. TurveyiD· 1 shared Ali FouladvandiD· 1 shared Allison MatthewsiD· 1 shared Alyssa E. JamesiD· 1 shared Andrea FinocchiiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersImmunology

Isabelle MeytsORCID

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2 papers

Recent·Most cited

C-terminal CDC42 variants in autoinflammatory patients specifically trigger actin defects and NF-kB hyperactivation

Alberto Iannuzzo, Philippe Mertz, Selket Delafontaine, Rachida Tacine, Guilaine Boursier, Véronique Hentgen, Sophie Georgin‐Lavialle, Isabelle Meyts, Jérôme Delon

The paper investigates four CDC42 variants in autoinflammatory patients, showing that C-terminal variants cause actin defects and NF-kB hyperactivation, while the N-terminal variant does not.

bioRxiv · Jun 26, 2024 · PreprintImmunology

Human Germline Heterozygous Gain-of-Function STAT6 Variants Cause Severe Allergic Disease

Mehul Sharma, Daniel Leung, Mana Momenilandi, Lauren C.W. Jones, Lucia Pacillo, Alyssa E. James, Jill R. Murrell, Selket Delafontaine, Jesmeen Maimaris, Maryam Vaseghi‐Shanjani, Kate L. Del Bel, Henry Y. Lu, Gilbert T. Chua, Silvia Di Cesare, Oriol Fornés, , Stuart E. Turvey

This study identifies heterozygous gain-of-function STAT6 variants in two patients with severe allergic disease and shows JAK inhibitors reduce the enhanced STAT6 responses.

The Journal of Experimental Medicine · Feb 10, 2023Peer-reviewedGenetic & Genomic Medicine