RNA G-quadruplexes forming scaffolds for alpha-synuclein aggregation lead to progressive neurodegeneration
Kazuya Matsuo, Sefan Asamitsu, Kohei Maeda, Hiroyoshi Suzuki, Kosuke Kawakubo, Ginji Komiya, Kenta Kudo, Yusuke Sakai, Karin Hori, Susumu Ikenoshita, Shingo Usuki, Shiori Funahashi, Hideki Oizumi, Atsushi Takeda, Yasushi Kawata, , Yasushi Yabuki
This study shows RNA G-quadruplexes scaffold alpha-synuclein aggregation, leading to neurodegeneration, and demonstrates that inhibiting this process can alleviate symptoms in a mouse model.
Cell · Oct 18, 2024Peer-reviewedMolecular Biology