Shingo Usuki

MEIOSIN retains an intrinsic STRA8-independent activity that drives meiotic entry across vertebrate evolution

The paper shows MEIOSIN has a STRA8-independent activity that drives meiotic entry in vertebrates, with different effects in zebrafish and mice.

MAP7-driven microtubule remodeling builds the Sertoli apical domain that supports timely meiotic progression

This study identifies MAP7 as a key regulator of microtubule remodeling in Sertoli cells, essential for apical domain formation and timely meiotic progression in mouse testes.

RNA G-quadruplexes forming scaffolds for alpha-synuclein aggregation lead to progressive neurodegeneration

This study shows RNA G-quadruplexes scaffold alpha-synuclein aggregation, leading to neurodegeneration, and demonstrates that inhibiting this process can alleviate symptoms in a mouse model.

Atypical heat shock transcription factor HSF5 is critical for male meiotic prophase under non-stress conditions

This study identifies HSF5 as a male germ cell-specific factor critical for meiotic prophase progression beyond pachytene under non-stress conditions.

Meiosis-specific ZFP541 repressor complex promotes meiotic prophase exit during spermatogenesis

This study identifies a ZFP541-KCTD19 repressor complex that promotes meiotic prophase exit in spermatogenesis by suppressing transcriptional regulators and chromatin modifiers.