Intron retention can be an excellent marker for evaluating the depressed state and useful for discovering new pathways in the recovery of depression by a drug.
Norihiro Okada, Kenshiro Oshima, Akiko Maruko, Mariko Sekine, Naoki Ito, Akino Wakasugi, Eiko Mori, Hiroshi Odaguchi, Yoshinori Kobayashi
The paper identifies intron retention (IR) as a biomarker for depression and shows its utility in discovering recovery pathways through RNA-seq analysis of peripheral blood mononuclear cells.
Frontiers in Psychiatry · Sep 19, 2024Peer-reviewedGenetic & Genomic Medicine