Stiffness Drives Endothelial Senescence and Inflammation in Aging and Doxorubicin-Induced Vascular Dysfunction
Camilla Romagnoli, Penelope M. Tsimbouri, Giuseppe Ciccone, Mariana Azevedo Gonzalez‐Oliva, Timo Z. Nazari Shafti, Massimo Vassalli, Delphine Gourdon
This study shows that vascular stiffness promotes endothelial senescence and inflammation, identifying extracellular matrix as a therapeutic target for aging and chemotherapy-induced vascular dysfunction.
bioRxiv · Feb 2, 2026 · PreprintBioengineering