Type I interferon drives a cellular state inert to TCR-stimulation and could impede effective T-cell differentiation in cancer
Dillon Corvino, Martin Druce Batstone, Brett G.M. Hughes, Tim Noah Kempchen, Susanna S. Ng, Nazhifah Salim, Franziska Schneppenheim, Denise Rommel, Ananthi Kumar, Sally‐Ann Pearson, Jason Madore, Lambross T. Koufariotis, Lisa Maria Steinheuer, Dilan Pathirana, Kevin Thurley, , Tobias Bald
The paper identifies a subset of CD8+ TILs in HPV-HNSCC enriched for interferon-stimulated genes that are transcriptionally inert to TCR stimulation and may hinder T-cell differentiation.
European Journal of Immunology · Nov 12, 2024Peer-reviewedImmunology