Impaired ERK MAPK activation in mature osteoblasts enhances bone formation via the mTOR pathway
Jung‐Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin R. Chaugule, Hyonho Chun, Marjolein C. H. van der Meulen, Ren Xu, Matthew Blake Greenblatt, Jae‐Hyuck Shim
The paper shows that inhibiting ERK in mature osteoblasts enhances bone formation through mTOR pathway activation, revealing a dual role of ERK in osteoblast differentiation.
eLife · Aug 17, 2022Peer-reviewedMolecular Biology