Author

Jae‐Hyuck Shim

University of Massachusetts Chan Medical SchoolORCID 0000-0002-4947-3293Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:drug response / drug discovery· 1 Approach:statistical model· 1

Frequent Co-Authors

Yeon-Suk Yang· 2 shared Anastasia KhvorovaiD· 1 shared Ashley SummersiD· 1 shared Bruktawit MaruiD· 1 shared Clemens LochmanniD· 1 shared David CooperiD· 1 shared Dimas EcheverriaiD· 1 shared Hassan H. FakihiD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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2 shared papersPharmacology & Toxicology

Yeon-Suk Yang

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2 papers

Recent·Most cited

Potent and durable gene modulation in heart and muscle with chemically defined siRNAs

Hassan H. Fakih, Clemens Lochmann, Rosemary Gagnon, Ashley Summers, Jillian Caiazzi, Julianna E. Buchwald, Qi Tang, Bruktawit Maru, Samuel R. Hildebrand, Mohammad Zain UI Abideen, Raymond C. Furgal, Katherine Y. Gross, Yeon-Suk Yang, David Cooper, Kathryn R. Monopoli, , Anastasia Khvorova

This study develops chemically defined siRNAs for durable gene modulation in muscle and heart, showing long-term silencing and functional benefits with minimal toxicity.

Nucleic Acids Research · Nov 26, 2025Peer-reviewedPharmacology & Toxicology

Impaired ERK MAPK activation in mature osteoblasts enhances bone formation via the mTOR pathway

Jung‐Min Kim, Yeon-Suk Yang, Jaehyoung Hong, Sachin R. Chaugule, Hyonho Chun, Marjolein C. H. van der Meulen, Ren Xu, Matthew Blake Greenblatt, Jae‐Hyuck Shim

The paper shows that inhibiting ERK in mature osteoblasts enhances bone formation through mTOR pathway activation, revealing a dual role of ERK in osteoblast differentiation.

eLife · Aug 17, 2022Peer-reviewedMolecular Biology