Pro-renin Receptor Inhibited ABCA1/G1 Expression Associated with Low HDL-c and Promoted Atherosclerosis
Yubing Dong, Wei Zhang, Wanyu Liu, Cuiping Bai, Ying Zhang, Yinong Jiang, Wei Song
This study shows that prorenin binding to (P)RR inhibits ABCA1/ABCG1 expression and cholesterol efflux, leading to dyslipidemia and atherosclerosis in hypertension.
bioRxiv · Apr 3, 2024 · PreprintPathology