Author

Emmanuelle Comets

InsermORCID 0000-0002-9150-9886Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Aurélie Barrail‐TraniD· 1 shared Bach NguyeniD· 1 shared Fabien CailléiD· 1 shared Moreno UrsinoiD· 1 shared Nicolas TournieriD· 1 shared Olivier LambotteiD· 1 shared Roger Le GrandiD· 1 shared Sébastien GoutaliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 36 mutual co-author links

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1 shared paperPharmacology & Toxicology

Aurélie Barrail‐TranORCID

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1 paper

Recent·Most cited

A novel workflow integrating whole-body PET microdosing data and therapeutic-dose pharmacokinetics across species to inform first-in-human dose selection

Bach Nguyen, Aurélie Barrail‐Tran, Moreno Ursino, Sébastien Goutal, Fabien Caillé, Thibaut Naninck, Roger Le Grand, Olivier Lambotte, Nicolas Tournier, Emmanuelle Comets

The paper develops a PET-informed PBPK model using micro- and conventional dose data from non-human primates to predict human dolutegravir pharmacokinetics and inform first-in-human dose selection.

bioRxiv · Sep 8, 2026 · PreprintPharmacology & Toxicology