Roger Le Grand

This paper develops a third-generation IL-2 therapeutic that targets inflamed tissues via oxidation-specific epitopes, showing improved therapeutic benefit in multiple inflammation models.

The paper develops a PET-informed PBPK model using micro- and conventional dose data from non-human primates to predict human dolutegravir pharmacokinetics and inform first-in-human dose selection.

This paper models how memory CD8 T cells can drive post-treatment control of HIV by analyzing SIV-infected non-human primate data and developing a mathematical framework.

This study shows that blocking LILRB1 and LILRB2 with a dual-specific antibody enhances antiviral immune responses in SIV infection without adverse effects.

This study identifies transcriptomic and phenotypic changes in neutrophils associated with disease progression in Mtb-infected macaques.

This study develops a mechanistic model of viral and antibody dynamics in non-human primates to quantify correlates of protection against SARS-CoV-2 infection.

This study shows that Lactobacillus crispatus enrichment in the vaginal microbiota of non-human primates reduces systemic inflammation and increases anti-CT IgG production during Chlamydia trachomatis infection.

The paper evaluates and re-annotates DNA methylation probes from two microarrays for use in two nonhuman primate species, identifying reliable probes for high-throughput methylation analysis.