Author

D H Wyllie

John Radcliffe HospitalORCID 0000-0002-9155-6228Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:whole-genome sequencing· 2 Research Focus:genome assembly· 1 Research Focus:variant calling· 1

Frequent Co-Authors

Ann Sarah WalkeriD· 2 shared Derrick W. CrookiD· 2 shared Tim PetoiD· 2 shared Alex OrlekiD· 1 shared Alison VaughaniD· 1 shared Amy J. MathersiD· 1 shared Andrew R. Dodgson· 1 shared Anna C. SealeiD· 1 shared

Activity by Year

2017-2019 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersGenomics

Ann Sarah WalkerORCID

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2 papers

Recent·Most cited

Genomic epidemiology of a complex, multi-species plasmid-borne blaKPC carbapenemase outbreak in Enterobacterales in the UK, 2009-2014

Nicole E Stoesser, HTT Phan, Anna C. Seale, Zoie A. Aiken, Stephanie Thomas, Matthew Thomas Smith, D H Wyllie, Ryan George, Robert Sebra, Amy J. Mathers, Alison Vaughan, Tim Peto, Matthew J. Ellington, Katie L. Hopkins, Derrick W. Crook, , the TRACE Investigators’ Group

This study analyzes the genomic epidemiology of a blaKPC carbapenemase outbreak in Enterobacterales in the UK, revealing genetic plasticity and plasmid dynamics across multiple species and lineages.

bioRxiv · Oct 3, 2019 · PreprintGenomics

Severe infections emerge from the microbiome by adaptive evolution

Bernadette Young, Chieh‐Hsi Wu, Nicola Claire Gordon, Kevin Cole, James Richard Price, Elian Liu, Anna E. Sheppard, Sanuki Perera, Jane Charlesworth, Tanya Golubchik, Zamin Iqbal, Rory J. Bowden, Ruth C. Massey, John Paul, Derrick W. Crook, , Daniel J. Wilson

Severe S. aureus infections arise from the nasal microbiome through adaptive evolution, with specific mutations enriched in infecting bacteria compared to colonizing ones.

eLife · Dec 19, 2017Peer-reviewedGenomics