Katie L. Hopkins

This study analyzes 1501 global genomes of multi-carbapenemase Enterobacterales, identifying common allelic combinations, plasmid distributions, and evolutionary mechanisms.

The paper constructs five panels of clinically relevant Gram-negative bacterial isolates to support antimicrobial and diagnostic development.

This study identifies two IncHI1 megaplasmids in Klebsiella species carrying blaIMP-1, showing transposable element-mediated mobilisation and conjugative transfer.

This study evaluates Nanopore long-read only genome assembly for clinical Enterobacterales isolates, finding Autocycler with Medaka polishing achieves accuracy comparable to hybrid assemblies.

The paper shows that E. coli phylogeny influences blaTEM-1 expression and co-amoxiclav resistance through lineage-specific regulatory differences.

This paper characterizes a Klebsiella pneumoniae isolate resistant to three beta-lactam/beta-lactamase inhibitor combinations, identifying genetic factors contributing to its resistance.

This study shows that plasmid conjugation is the main driver of within-patient plasmid diversity, as most patients share identical OXA-48 plasmids across different bacterial hosts.

This study analyzes the genomic epidemiology of a blaKPC carbapenemase outbreak in Enterobacterales in the UK, revealing genetic plasticity and plasmid dynamics across multiple species and lineages.