Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity
Stephen R. Doyle, Catherine Bourguinat, Hugues Clotaire Nana-Djeunga, Jonas Arnaud Kengne-Ouafo, Sébastien D. S. Pion, Jean Gabin Bopda, Joseph Kamgno, Samuel Wanji, Hua Che, Annette C. Kuesel, Martin Walker, Marı́a-Gloria Basáñez, Daniel Adjei Boakye, Mike Yaw Osei-Atweneboana, Michel Boussinesq, , Warwick N. Grant
This study uses genome-wide analysis to show that genetic drift and soft selective sweeps, rather than strong selection, drive loss of ivermectin sensitivity in Onchocerca volvulus.
PLoS neglected tropical diseases · Jul 26, 2017Peer-reviewedGenomics