Stephen R. Doyle

The paper identifies sex-biased transcriptional changes and genetic loci associated with eprinomectin resistance in Haemonchus contortus using genomic and transcriptomic analyses.

The paper compares ambient temperature storage methods for parasitic nematode larvae before whole-genome sequencing, finding DESS buffer performs better than FTA cards for individual larvae but comparable results for pooled samples.

TRPtracker aggregates TRPMPZQ variants and their PZQ sensitivity data to monitor resistance and support schistosomiasis control strategies.

This study establishes an in vitro system using caecaloids to recapitulate whipworm development, showing that larvae develop anatomical features and growth patterns similar to in vivo conditions.

Whole-genome sequencing of 127 adult Dirofilaria immitis from four continents reveals continental population structure predating dog domestication, an Asian source for Australian worms, and recent Europe-Central America spread.

The paper assesses genetic diversity of soil-transmitted helminths across regions and evaluates its impact on molecular diagnostic targets using low-coverage genome sequencing and in vitro assays.

This paper develops a hybridization capture method to enrich mitochondrial genomes of soil-transmitted helminths from fecal samples, achieving high enrichment and sensitivity.

The paper generates a chromosome-scale genome assembly for Teladorsagia circumcincta and identifies genetic loci associated with drug resistance to improve anthelmintic resistance diagnostics.

This study identifies serine proteases as key mediators of whipworm egg hatching induced by bacterial contact, revealing bacterial and larval enzyme interactions.

This paper optimizes single-nuclei isolation and RNA sequencing for parasitic nematodes, improving yield and RNA quality across life stages and sexes.

The paper uses population genomics and functional genetics to identify praziquantel resistance variants in Schistosoma mansoni.

This study provides a comprehensive transcriptomic analysis of Schistosoma mansoni across eight life stages, revealing sex-specific gene expression patterns and developmental transitions.

This study improves the genome assembly of Dirofilaria immitis and analyzes global genetic structure to understand resistance to macrocyclic lactone drugs.

This study presents the first population genomics analysis of Trichuris trichiura using whole-genome sequencing of ancient and modern samples, revealing genetic structure and admixture patterns across human and primate hosts.

The paper analyzes whole-genome sequences of Schistosoma mansoni from Ugandan fishing communities to assess population structure and genetic changes associated with praziquantel treatment.

The paper maps resistance loci for three anthelmintic classes in a parasitic nematode, identifies novel alleles for benzimidazoles and levamisole, and implicates cky-1 in ivermectin resistance.

This paper identifies gene expression changes associated with ivermectin resistance in parasitic nematodes through genetic crosses and RNA-seq, revealing upregulation of specific genes linked to neuronal plasticity and chloride homeostasis.

The paper assembles the chromosomes of Schistosoma mansoni, revealing insights into the evolution of its ZW sex-determination system through gene annotation and synteny analysis.

This study creates a single-cell RNA sequencing atlas of the early intra-mammalian stage of Schistosoma mansoni, identifying gene expression profiles and validating cell markers.

The paper uses genomic data from Guinea worm infections in humans and dogs to show they originate from the same population, indicating transmission between species and a population bottleneck.

The paper presents a high-quality, chromosome-scale genome assembly of Haemonchus contortus using long-read sequencing, revealing genetic diversity and transcriptional regulation.

The paper presents the complete genome of Hymenolepis microstoma, revealing chromosome structures capped by centromeres that serve both segregation and protection roles.

The paper evaluates DNA extraction methods for whole genome sequencing of individual helminth eggs and larvae, showing successful sequencing for six of eight species tested.

This study analyzes the global genetic diversity of Haemonchus contortus, revealing human-driven dispersal and climate adaptation mechanisms.

The paper identifies a single major QTL on chromosome V associated with ivermectin resistance in Haemonchus contortus through genome-wide analysis of genetic crosses.

This study uses ddRADseq to reveal six species within the Octopus vulgaris complex, finding mito-nuclear discordance and suggesting recent speciation during global cooling.

The paper estimates Wolbachia density in different life stages of Onchocerca volvulus and finds lower variation in microfilariae and vector stages compared to adults.

This paper compares genomes of 81 nematode and platyhelminth species to identify gene families related to parasitism and prioritize new drug targets.

This paper constructs a genetic map of Haemonchus contortus using whole-genome resequencing, revealing recombination patterns and reproductive traits like polyandry and polyploidy.