Hypoglycosylation lowers the mechanical activation threshold of Piezo1 and enhances cortical neuronal mechanotransduction: implications for PMM2-CDG
ALBERT EDO-PEREZ, Gorane Rodríguez-Urquirizar, ALICIA FERNANDEZ-ARROYO, Julia Carrillo-García, José M. Fernández‐Fernández
This study shows that hypoglycosylation lowers the mechanical activation threshold of Piezo1, enhancing mechanotransduction in cortical neurons and linking glycosylation defects to neurological symptoms in PMM2-CDG.
bioRxiv · Aug 7, 2026 · PreprintNeuroscience