Cancer BiologybioRxivPreprint
Alphavirus replicon particle expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunity
Momoko Ishikawa, Dhanya K. Nambiar, Jaya Sastri…·Wataru Akahata
This study uses an alphavirus replicon particle expressing IL-12 to reprogram immunosuppressive tumor-associated macrophages and neutrophils, enhancing anti-tumor immunity and reducing tumor growth in mouse models.
DOI 10.1101/2025.08.07.666585