Alphavirus replicon particle expressing IL-12 reprograms tumor-associated macrophages and neutrophils and induces anti-tumor immunity
Momoko Ishikawa, Dhanya K. Nambiar, Jaya Sastri, Forrest Bowling, Keiko Ishimoto, Fumiya Tao, Koyo Takahashi, Ivan Stephanek, Hongbin Cao, Davis Leitner, Kenta Matsuda, Fred M. Baik, John B. Sunwoo, Quynh‐Thu Le, Jonathan Smith, Wataru Akahata
This study uses an alphavirus replicon particle expressing IL-12 to reprogram immunosuppressive tumor-associated macrophages and neutrophils, enhancing anti-tumor immunity and reducing tumor growth in mouse models.
bioRxiv · Aug 7, 2025 · PreprintCancer Biology