L-Asparaginase treatment induces reversible immunoregulatory and immunosuppressive effects in non-malignant B cells in a model of T-cell dependent B cell activation
Amar Hadzic, Maria Alejandra Garcia-Marquez, Pol Bannasch, Nina Haindl, Katharina Frey, Martin Kirmaier, Maximilian A. Funk, Anneli Tischmacher, Jingke Tu, Adriano Carboniero, Ludovica Vona, Sabine Oganesian, Lena Muschik, Hans Schlößer, Martin Vaeth, , Sebastian Theurich
This study shows L-asparaginase reduces B cell proliferation and function, induces a regulatory B cell phenotype, and may have immunosuppressive effects on non-malignant B cells.
iScience · Aug 1, 2026Peer-reviewedImmunology