Martin Vaeth

This study shows that GLUT3 is essential for Treg cell function and immune regulation, challenging the idea that Treg cells rely mainly on mitochondrial metabolism.

This study shows L-asparaginase reduces B cell proliferation and function, induces a regulatory B cell phenotype, and may have immunosuppressive effects on non-malignant B cells.

This study shows that MYC suppresses lysosomal protein degradation in pancreatic ductal adenocarcinoma, promoting immune evasion by altering amino acid availability and immune cell responses.

This study shows that Tafazzin-mediated cardiolipin remodeling is essential for metabolic stress response and effector function of inflammatory T cells, with implications for Barth syndrome.

This study shows CD8+ T cells drive energy substrate redistribution between lymphoid organs and the heart during viral infection, with metabolic adaptations affecting cardiac function.

This study shows that glucose uptake via GLUT1/3 is essential for neutrophil oxidative burst and lipid mediator production during microbial infection.

This study uses single-cell RNA-sequencing and spatial transcriptomics to analyze the spatio-temporal dynamics of the fibrotic niche in cardiac repair after ventricular injury in adult mice, identifying key cell interactions and regulatory mechanisms.