Cancer BiologybioRxivPreprint
Pan-cancer prediction of tumor immune activation and response to immune checkpoint blockade from tumor transcriptomics and histopathology
Sumit Mukherjee, Sumeet Patiyal, Lipika R. Pal…·Eytan Ruppin
This paper introduces TIME_ACT, a transcriptomic signature predicting immune checkpoint blockade response across cancers, validated using histopathology and multiple cohorts.
DOI 10.1101/2025.06.27.661875