NeuroscienceNeurobiology of DiseasePeer-reviewed
Gut transit and gut microbiome changes occur prior to the onset of motor impairment in a mouse model of Machado-Joseph disease
Vasilisa Zvyagina, Andrea Kuriakose, Ignacio Simó…·Angela S. Laird
This study shows that gut microbiome changes and colonic dysfunction occur before motor impairments in MJD mice, suggesting inflammation and endocrine factors may link gut and brain in disease progression.
DOI 10.1016/j.nbd.2025.107121