Ian T. Paulsen

The paper generates genomic diversity in bacteria through large-scale reconfigurations to study phenotypic robustness to genome organization changes.

This study shows that gut microbiome changes and colonic dysfunction occur before motor impairments in MJD mice, suggesting inflammation and endocrine factors may link gut and brain in disease progression.

This study identifies 136 genes involved in swarming motility of Pseudomonas protegens Pf-5 using TraDIS, revealing new pathways beyond flagella-related functions.

This study uses metabarcoding to analyze how environmental and nutritional factors influence the gut microbiome of invasive bumblebees in Tasmania.

The paper shows agriculture increases positive selection on nitrate reduction genes in soil bacteria globally, altering protein evolution in key microbial processes.

This study identifies 249 genes involved in swimming motility of Pseudomonas protegens Pf-5 using TraDIS, revealing novel gene functions and a link between phosphate transport and motility.

The paper debugs a synthetic yeast chromosome and uses laboratory evolution to identify genomic rearrangements that suppress growth defects caused by synthetic modifications.

The paper develops synthetic minimal UPR sensors in yeast to improve the detection of ER stress for optimizing heterologous protein production.

This study identifies essential genes in Pseudomonas protegens Pf-5 using transposon insertion sequencing, revealing differences in essentiality compared to P. aeruginosa PA14.

This paper engineers methanol assimilation pathways in yeast and identifies a latent methylotrophic metabolism, improving growth and metabolite labeling through genetic modifications.