Calorie restriction leads to degradation of mutant uromodulin and ameliorates inflammation and fibrosis in UMOD-related kidney disease
Mariapia Giuditta Cratere, Benedetta Perrone, Barbara Canciani, Céline Schaeffer, Luca Rampoldi
This study shows calorie restriction reduces mutant uromodulin retention, alleviates inflammation, and improves kidney function in a mouse model of UMOD-related kidney disease.
Journal of the American Society of Nephrology · Feb 3, 2026Peer-reviewedGenetics