Luca Rampoldi

This study identifies altered thick ascending limb cells with UMOD retention as drivers of CKD using spatial proteomics and shows reducing UMOD retention attenuates CKD development.

This study shows calorie restriction reduces mutant uromodulin retention, alleviates inflammation, and improves kidney function in a mouse model of UMOD-related kidney disease.

The paper shows Uromodulin forms salt-dependent velcro-like sheets that interact with UPEC pili, revealing structural mechanisms for UTI protection.

This study investigates allelic and gene dosage effects of UMOD mutations in ADTKD, showing toxic aggregates and ER stress contribute to kidney disease progression.

The paper identifies an intermediate-effect variant in UMOD associated with chronic kidney disease risk and shows it has reduced disease severity compared to canonical ADTKD mutations.