Ashfaqul M. Alam

Single-cell profiling reveals disruption of cell-cycle homeostasis following JDP2 depletion in colorectal epithelial cells

This study shows JDP2 depletion disrupts cell-cycle homeostasis in colorectal epithelial cells, increasing proliferation and altering transcriptional states.

Campylobacter jejuni Infection Is Associated With Cell-Cycle, Redox, and Metabolic Remodeling of Human Intestinal Epithelial Cells at Single-Cell Resolution

This study uses single-cell RNA sequencing to show that C. jejuni infection alters cell-cycle, redox, and metabolic states in human intestinal epithelial cells.

Pro-restitutive Bacteroides thetaiotaomicron reprograms the transcriptome of intestinal epithelial cells by modulating the expression of genes essential for proliferation and migration.

This study shows that Bacteroides thetaiotaomicron modulates gene expression in intestinal epithelial cells to promote mucosal repair and barrier function during gut inflammation resolution.

Microbial Metabolite Trimethylamine N-Oxide Promotes Campylobacter jejuni Infection by Escalating Intestinal Inflammation, Epithelial Damage, and Barrier Disruption

This study shows that TMAO, a microbial metabolite, enhances C. jejuni infection by increasing intestinal inflammation, epithelial damage, and barrier disruption.