SH3BP2 regulates the organization of the neuromuscular synapses through protein-driven phase separation
Bhola Shankar Pradhan, Krzysztof M. Bernadzki, Yauhen Bandaruk, Anna Siudzińska, Teresa De Cicco, Marta Gawor, Joanna Krzemień, Grzegorz Chodaczek, Said Hashemolhosseini, Tomasz J. Prószyński
This study identifies SH3BP2 as a regulator of neuromuscular synapse organization by promoting AChR clustering through phase separation, and shows its deletion causes synaptic defects in mice.
bioRxiv · May 23, 2024 · PreprintNeuroscience