DCLRE1A orchestrates CAG repeat contraction following Cas12a-induced DNA breaks
Magdalena Dabrowska, Sebastian M. Siegner, Anna Misiukiewicz, Yauhen Bandaruk, Markus Schröder, Matthias Muhar, Susanne Kreutzer, Jacob E. Corn, Marta Olejniczak
This study identifies DCLRE1A as a key factor in CAG repeat contraction following Cas12a-induced DNA breaks and demonstrates its role in enhancing repeat shortening through interactions with repair proteins.
bioRxiv · Nov 18, 2025 · PreprintCell Biology