Polygenic and familial contributions to antidepressant continuation, switching, discontinuation and augmentation in the All of Us and Pharmlines cohorts
Alicia Walker, Xiaotong Wang, Jens Bos, Tian Lin, Frank Klont, Ilja M. Nolte, Harold Snieder, Roeland Broekema, Peter M. Visscher, Anjali K. Henders, Catharina Annette Hartman, Hanna M. van Loo, Maxime Taquet, Eelko Hak, Naomi R. Wray
The paper investigates polygenic and familial factors influencing antidepressant treatment outcomes in two cohorts, finding associations between depression polygenic scores and treatment switching, with some links to schizophrenia and bipolar disorder.
medRxiv · Sep 8, 2026 · PreprintGenetic & Genomic Medicine