The paper examines the relationship between white matter microstructure, measured by fractional anisotropy, and transition to psychosis in individuals at clinical high risk, finding directionally consistent but small associations.

bioRxiv · Sep 30, 2026 · PreprintNeuroscience

Polygenic and familial contributions to antidepressant continuation, switching, discontinuation and augmentation in the All of Us and Pharmlines cohorts

Alicia Walker, Xiaotong Wang, Jens Bos, Tian Lin, Frank Klont, Ilja M. Nolte, Harold Snieder, Roeland Broekema, Peter M. Visscher, Anjali K. Henders, Catharina Annette Hartman, Hanna M. van Loo, Maxime Taquet, Eelko Hak, Naomi R. Wray

The paper investigates polygenic and familial factors influencing antidepressant treatment outcomes in two cohorts, finding associations between depression polygenic scores and treatment switching, with some links to schizophrenia and bipolar disorder.

medRxiv · Sep 8, 2026 · PreprintGenetic & Genomic Medicine

Longitudinal White Matter Trajectories in Clinical High Risk and First-Episode Psychosis: Findings from the Multi-Centre PSYSCAN Study

Lara Bolte, George Gifford, Maurício Henriques Serpa, Michiel Cottaar, Paola Dazzan, Paolo Fusar‐Poli, Stefania Tognin, Matthew J. Kempton, Inge Winter-van Rossum, Margot I. E. Slot, Hendrika van Hell, Arija Maat, Lieuwe de Haan, Benedicto Crespo Facorro, Birte Glenthøj, , Philip K. McGuire

The paper examines longitudinal white matter changes in early psychosis using diffusion tensor imaging and finds no significant group differences or associations with symptom progression, but links antipsychotic medication dose to lower fractional anisotropy.

bioRxiv · Jul 22, 2026 · PreprintNeuroscience