Brain permeable AMPK activator R481 raises glycemia by autonomic nervous system activation and amplifies the counterregulatory response to hypoglycemia in rats
Ana Miguel Cruz, Yasaman Malekizadeh, Julia M. Vlachaki Walker, Paul G. Weightman Potter, Katherine R. Pye, Simon J. Shaw, Kate L. J. Ellacott, Craig Beall
The paper shows that R481, a brain-permeable AMPK activator, raises blood glucose and enhances counterregulatory responses to hypoglycemia in rats without affecting insulin sensitivity.
bioRxiv · Aug 29, 2019 · PreprintNeuroscience