Katherine R. Pye

Validation of a refined protocol for mouse oral glucose tolerance testing without gavage

This paper validates a refined, non-invasive method for mouse oral glucose tolerance testing that avoids gavage, showing reduced stress and improved consistency in glucose tolerance measurements.

Regulation of astrocyte metabolism by mitochondrial translocator protein 18kDa

This study investigates the role of TSPO in astrocyte metabolism and inflammation, finding that TSPO deficiency alters metabolic flexibility but not the inflammatory response to LPS.

Astrocytes in the dorsal vagal complex are not activated by systemic glucoprivation and their chemogenetic activation does not elicit homeostatic glucoregulatory responses in mice

This study shows DVC astrocytes do not respond to systemic glucoprivation and their activation does not restore blood glucose in mice.

Brain permeable AMPK activator R481 raises glycemia by autonomic nervous system activation and amplifies the counterregulatory response to hypoglycemia in rats

The paper shows that R481, a brain-permeable AMPK activator, raises blood glucose and enhances counterregulatory responses to hypoglycemia in rats without affecting insulin sensitivity.