Cosmin Tudose

This paper constructs a comprehensive annotated dataset of human E3 ligases and uses a hierarchical classification framework to analyze their functional and structural relationships.

This study investigates how PRC2 depletion in AML affects epigenomic and transcriptional changes, revealing altered chromatin accessibility, H3K27me3 levels, and gene expression patterns that impact cell phenotype and treatment response.

The paper assesses whether gene regulatory networks can predict gene sensitivity in cancer cell lines and finds that mRNA abundance is a better predictor than inferred regulatory activity.