Choice suppression is achieved through opponent but not independent function of the striatal indirect pathway in mice
Kristen M. Delevich, Benjamin D. Hoshal, Lexi Z. Zhou, Yuting Zhang, Satya V. Vedula, Wan Chen Lin, Juliana B. Chase, Anne Gabrielle Eva Collins, Linda Wilbrecht
This study investigates the role of the indirect pathway in choice suppression using chemogenetic manipulation in mice, finding that activation, not inhibition, of iSPNs disrupts suppression of nonrewarded choices.
Cell Reports · Jul 1, 2022Peer-reviewedNeuroscience