Linda Wilbrecht

This study identifies genomic signatures of selection in Mus spicilegus, revealing accelerated evolution in brain-active genes linked to seasonal development and mound-building behavior.

The paper compares task information encoding in adolescent and adult mouse frontal cortex, finding stronger population-level encoding in adolescents despite similar single-cell encoding.

This study investigates how prepubertal gonadectomy affects dopamine release in the nigrostriatal and mesoaccumbal systems of wild-derived mice, finding reduced release in the nigrostriatal system but not the mesoaccumbal.

This paper develops flexible optical fibers functionalized with SWNT-based sensors for detecting catecholamines, showing reliable performance in clinical biofluids and brain slices.

The paper investigates reinforcement learning in male and female mice with ASD-linked mutations, finding enhanced learning in males but not females, with effects modulated by reward uncertainty.

This study shows adolescent and adult mice use both reinforcement learning and short-term memory strategies to learn a conditional odor association task, with no developmental difference in learning rates but increased reliance on perseverative strategies in males.

This study shows that ventral hippocampus CA1 is necessary for mice to perform hidden state inference in a 2-armed bandit task using abstract contextual representations.

The paper investigates assumptions about parameter generalization and interpretability in reinforcement learning models across different tasks and participants.

This study investigates the role of the indirect pathway in choice suppression using chemogenetic manipulation in mice, finding that activation, not inhibition, of iSPNs disrupts suppression of nonrewarded choices.

This study finds adolescents outperform younger and older participants in a stochastic reversal-learning task, with optimal RL and BI parameters and unique processing of positive feedback.

This study investigates how probabilistic reinforcement learning changes with age during adolescence and adulthood, finding increased learning rates and decreased exploration with age, and a link between testosterone and learning rates in mid-adolescence.

This study shows that prepubertal ovariectomy in female mice alters decision-making strategies and DMS neuron excitability, affecting explore/exploit balance during reversal learning.

The paper examines how sex and pubertal status affect dendritic spine density in frontal corticostriatal projection neurons in mice, finding sex differences and pubertal regulation in spine pruning.

This study investigates how reinforcement learning and working memory contribute to learning changes during adolescence, finding greater developmental changes in reinforcement learning than working memory.

This paper introduces a non-genetically encoded near-infrared fluorescent nanosensor to image dopamine release in brain tissue with high spatial and temporal resolution.