Dissecting the Predictive Accuracy of Polygenic Indexes for Behavioral Phenotypes Across Genetic Ancestries
Robel G. Alemu, Alexander S. Young, Daniel Jacob Benjamin, Patrick Turley, Aysu Okbay
This study evaluates the portability of polygenic indexes for behavioral traits across genetic ancestries, finding reduced accuracy in non-European populations and factors contributing to this loss.
bioRxiv · Sep 11, 2025 · PreprintGenetics