Aysu Okbay

The paper examines how polygenic indices for educational attainment change across birth cohorts and regions in Germany, finding stronger associations in recent cohorts and the East but weaker effects for women.

The paper examines developmental correlates of epigenetic and polygenic indices of cognition and education from birth to young adulthood, finding Epigenetic-g is plastic in early childhood and captures distinct variation from polygenic indices.

This study evaluates the portability of polygenic indexes for behavioral traits across genetic ancestries, finding reduced accuracy in non-European populations and factors contributing to this loss.

This study links preschool musicality to school-age communication abilities through genetic factors related to rhythmicity using polygenic scores and structural equation modeling.

The paper updates a polygenic index repository with more phenotypes, datasets, and improved causal inference methods, enhancing predictive performance and interpretability.

Family-based GWAS meta-analysis of 34 phenotypes shows standard GWAS effects carry sizeable confounding uncorrelated with direct genetic effects, while assortative mating likely inflates SNP heritability and genetic correlations.

The paper finds stronger polygenic associations with educational attainment in East Germans after reunification compared to West Germans.

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

The paper describes the Gene-SOEP dataset, a longitudinal genetic study of 2,598 individuals in Germany, providing polygenic indices for research on genetic-environment interactions.

The paper develops a method to impute parental genotypes from sibling data to estimate direct and indirect genetic effects, finding that standard GWAS underestimates direct effects for several traits.

This study performs a multivariate GWAS on psychiatric disorders and symptoms to identify two genetic liabilities distinguishing common mood disturbances from serious mental illnesses.

The paper constructs polygenic indexes for 47 phenotypes across 11 datasets and provides a tool to correct errors-in-variables bias when using PGIs as proxies for the additive SNP factor.

This study identifies genetic loci associated with macronutrient intake and links them to health outcomes using GWAS in over 235,000 individuals.

The paper investigates polygenic associations between ADHD and literacy/language abilities, finding that genetic confounding with educational attainment masks ADHD-specific reading impairments.

GWAS in over one million individuals identify 611 loci across risk tolerance and risky behaviors, revealing shared genetic architecture and implicating glutamatergic and GABAergic neurotransmission.

This study uses genome-wide association data for educational attainment and schizophrenia to identify genetic heterogeneity and novel candidate genes for schizophrenia.

MTAG improves GWAS results by combining summary statistics across traits, increasing significant loci and enhancing polygenic score variance.

This study uses polygenic scores to examine if genetic factors buffer against depressive symptoms after spouse death in older adults, finding small protective effects.

The paper uses polygenic transmission disequilibrium to show common and rare variants act additively in autism risk, with polygenic risk over-transmitted to ASD cases but not unaffected siblings.

The paper identifies genetic variants associated with subjective well-being, depressive symptoms, and neuroticism using genome-wide association studies and proxy-phenotype analyses.