Targeting with structural analogs of natural products the purine salvage pathway in Leishmania (Leishmania) infantum by computer-aided drug design approaches
Haruna Luz Barazorda-Ccahuana, Eymi Gladys Cárcamo Rodriguez, Angela Emperatriz Centeno-Lopez, Alexsandro Sobreira Galdino, Ricardo Andrez Machado‐de‐Ávila, Rodolfo Cordeiro Giunchetti, Eduardo Antonio Ferraz Coelho, Miguel Á. Chávez‐Fumagalli
This study identifies structural analogs of natural products that target the purine salvage pathway in Leishmania infantum using computer-aided drug design, showing good binding affinity and potential for oral administration.
Tropical Medicine and Infectious Disease · Feb 3, 2024Peer-reviewedBioinformatics